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Treatment of Chronic Obstructive Pulmonary Disease with Roflumilast, a New Phosphodiesterase 4 InhibitorGROSS, Nicholas J; GIEMBYCZ, Mark A; RENNARD, Stephen I et al.COPD (Monticello (Sullivan County, N.Y.)). 2010, Vol 7, Num 2, pp 141-153, issn 1541-2555, 13 p.Article

Roflumilast with long-acting β2-agonists for COPD: influence of exacerbation historyBATEMAN, E. D; RABE, K. F; CALVERLEY, P. M. A et al.The European respiratory journal. 2011, Vol 38, Num 3, pp 553-560, issn 0903-1936, 8 p.Article

Lack of DNA binding in the rat nasal mucosa and other tissues of the nasal toxicants roflumilast, a phosphodiesterase 4 inhibitor, and a metabolite, 4-amino-3,5-dichloropyridine, in contrast to the nasal carcinogen 2,6-dimethylanilineJEFFREY, Alan M; LUO, Feng-Qi; AMIN, Shantilal et al.Drug and chemical toxicology (New York, NY. 1978). 2002, Vol 25, Num 1, pp 93-107, issn 0148-0545Article

The phosphodiesterase 4 inhibitor roflumilast is effective in the treatment of allergic rhinitisSCHMIDT, Bernhard M. W; KUSMA, Matthias; FEURING, Martin et al.Journal of allergy and clinical immunology. 2001, Vol 108, Num 4, pp 530-536, issn 0091-6749Article

Roflumilast, a phosphodiesterase 4 inhibitor, reduces airway hyperresponsiveness after allergen challengeLOUW, C; WILLIAMS, Z; VENTER, L et al.Respiration (Basel). 2007, Vol 74, Num 4, pp 411-417, issn 0025-7931, 7 p.Article

Pharmacology, Clinical Efficacy, and Tolerability of Phosphodiesterase-4 Inhibitors: Impact of Human PharmacokineticsTENOR, Hermann; HATZELMANN, Armin; BEUME, Rolf et al.Handbook of experimental pharmacology. 2011, Vol 204, pp 85-119, issn 0171-2004, 35 p.Article

Physiological effects of roflumilast at rest and during exercise in COPDO'DONNELL, Denis E; BREDENBRÖKER, Dirk; BROSE, Manja et al.The European respiratory journal. 2012, Vol 39, Num 5, pp 1104-1112, issn 0903-1936, 9 p.Article

The potential role of roflumilast : The new phosphodiesterase-4 inhibitorKARISH, Sarah B; GAGNON, James M.The Annals of pharmacotherapy. 2006, Vol 40, Num 6, pp 1096-1104, issn 1060-0280, 9 p.Article

Roflumilast inhibits the release of chemokines and TNF-α from human lung macrophages stimulated with lipopolysaccharideBUENESTADO, A; GRASSIN-DELYLE, S; GUITARD, F et al.British journal of pharmacology. 2012, Vol 165, Num 6, pp 1877-1890, issn 0007-1188, 14 p.Article

Roflumilast inhibits leukocyte-endothelial cell interactions, expression of adhesion molecules and microvascular permeabilitySANZ, M.-J; CORTIJO, J; HATZELMANN, A et al.British journal of pharmacology. 2007, Vol 152, Num 4, pp 481-492, issn 0007-1188, 12 p.Article

Roflumilast N-oxide, a PDE4 inhibitor, improves cilia motility and ciliated human bronchial epithelial cells compromised by cigarette smoke in vitroMILARA, J; ARMENGOT, M; BANULS, P et al.British journal of pharmacology. 2012, Vol 166, Num 8, pp 2243-2262, issn 0007-1188, 20 p.Article

Roflumilast: A Novel Treatment for Chronic Obstructive Pulmonary DiseaseREID, Debra J; PHAM, Nga T.The Annals of pharmacotherapy. 2012, Vol 46, Num 4, pp 521-529, issn 1060-0280, 9 p.Article

Roflumilast Increases Clara Cell Secretory Protein in Cigarette Smoke-Exposed MiceXIAO NA GE; HONG WEI CHU; MINOR, Maisha N et al.COPD (Monticello (Sullivan County, N.Y.)). 2009, Vol 6, Num 3, pp 185-191, issn 1541-2555, 7 p.Article

Direct metal-catalyzed tritiation of organic compoundsFILER, Crist N.Journal of labelled compounds & radiopharmaceuticals. 2010, Vol 53, Num 11-12, pp 739-744, issn 0362-4803, 6 p.Article

Simultaneous quantitation of IC87114, roflumilast and its active metabolite roflumilast N-oxide in plasma by LC-MS/MS: application for a pharmacokinetic studyTHAPPALI, Satheeshmanikandan R S; VARANASI, Kanthikiran V. S; VEERARAGHAVAN, Sridhar et al.Journal of mass spectrometry. 2012, Vol 47, Num 12, pp 1612-1619, issn 1076-5174, 8 p.Article

Population Pharmacokinetic Modelling of Roflumilast and Roflumilast N-Oxide by Total Phosphodiesterase-4 Inhibitory Activity and Development of a Population Pharmacodynamic-Adverse Event ModelLAHU, Gezim; HÜNNEMEYER, Andreas; DILETTI, Edgar et al.Clinical pharmacokinetics. 2010, Vol 49, Num 9, pp 589-606, issn 0312-5963, 18 p.Article

Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trialsCALVERLEY, Peter M. A; RABE, Klaus F; GOEHRING, Udo-Michael et al.Lancet (British edition). 2009, Vol 374, Num 9691, pp 685-694, issn 0140-6736, 10 p.Article

Efficacy and safety of roflumilast in the treatment of asthmaBATEMAN, Eric D; IZQUIERDO, Jose Luis; HARNEST, Ulf et al.Annals of allergy, asthma, & immunology. 2006, Vol 96, Num 5, pp 679-686, issn 1081-1206, 8 p.Article

Phosphodiesterase 4 Inhibitor Roflumilast Improves the Bronchodilative Effect of Sevoflurane in Sensitized AirwaysJING ZHOU; IWASAKI, Sohshi; YAMAKAGE, Michiaki et al.Anesthesiology (Philadelphia). 2014, Vol 120, Num 5, pp 1152-1159, issn 0003-3022, 8 p.Article

24/7 Intensivist Coverage, Macrolides in Acute Lung Injury, and RoflumilastAMIN, Emily N; MCCANN, Edward T; MIECZKOWSKI, Brian P et al.American journal of respiratory and critical care medicine. 2013, Vol 187, Num 4, pp 446-447, issn 1073-449X, 2 p.Article

Roflumilast: an oral anti-inflammatory treatment for chronic obstructive pulmonary disease: a randomised controlled trialRABE, Klaus F; BATEMAN, Eric D; O'DONNELL, Denis et al.Lancet (British edition). 2005, Vol 366, Num 9485, pp 563-571, issn 0140-6736, 9 p.Article

Phosphodiesterase 4 inhibitors for the treatment of COPDSTURTON, Graham; FITZGERALD, Mary.Chest. 2002, Vol 121, Num 5, pp 192S-196S, issn 0012-3692Conference Paper

Innovations thérapeutiques dans le traitement de l'asthme et de la BPCO : inhibiteurs des PDE4, atropiniques et corticostéroïdes = New therapeutic agents for the treatment of asthma and COPD : PDE4 inhibitors, atropine derivatives and corticosteroidsDE BLAY, F; BARNIG, C.Revue française d'allergologie et d'immunologie clinique. 2006, Vol 46, Num 3, pp 252-256, issn 0335-7457, 5 p.Conference Paper

Disease-modifying effect of ASP3258, a novel phosphodiesterase type 4 inhibitor, on subchronic cigarette smoke exposure-induced lung injury in guinea pigsKUBO, Satoshi; KOBAYASHI, Miki; IWATA, Masahiro et al.European journal of pharmacology. 2011, Vol 659, Num 1, pp 79-84, issn 0014-2999, 6 p.Article

Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary diseaseRABE, Klaus F.British journal of pharmacology. 2011, Vol 163, Num 1, pp 53-67, issn 0007-1188, 15 p.Article

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